What is Venetoclax used for?
Chronic Lymphocytic Leukemia (CLL): Venetoclax is used for the treatment of adults with CLL. It is prescribed with another drug named obinutuzumab. This is used when CLL has not been treated earlier. Venetoclax can be used with another drug named rituximab. This is used when CLL has recurrence or has not responded to treatment. Venetoclax can also be used by itself when CLL has a chromosome deletion and has recurrence or has not responded to treatment; or has no chromosome deletion and other therapies are unavailable.
Chronic Lymphocytic Leukemia is a type of cancer that primarily affects the lymph nodes and WBCs named “B lymphocytes”. In this disease, unhealthy B lymphocytes multiply rapidly and live excessively. This causes there to be excess of them in the blood.
Acute Myeloid Leukemia (AML): Venetoclax is used for the treatment of adults with Acute Myeloid Leukemia whose disease has not been treated earlier, and who are at least aged 75 years or have medical conditions that prevent them from having other types of chemo. For these patients, venetoclax 100 mg should be taken with another medication. It could be either azacitidine or low-dose cytarabine.
Acute Myeloid Leukemia (AML) is a cancer of the bone marrow and the blood. It primarily affects WBCs that are not fully mature known as myeloid blasts. In this disease, there are changes in the myeloid blasts that inhibit them from becoming mature blood cells. These immature blasts build up in the bone marrow and blood. This inhibits the normal cells from being produced and causes there to be a lower number of healthy blood cells.
Mechanism of Action: Venetoclax works in order to inhibit a protein in the body named BCL-2. This is a specific protein that helps cancerous cells survive. Inhibiting this protein helps to destroy and reduce the number of cancerous cells.
How to take VENCLEXTA?
The venclexta 100 mg tablet should always be taken exactly as your healthcare practitioner tells you. Drink plenty of water when taking treatment with this medication to help reduce the risk of getting TLS. Tablets should be administered with a meal and water at the same time each day. Swallow the tablets of venclexta whole. Do not chew, crush, or break the tablets. Your doses may be lower in some cases, including if you have severe liver problems, or in case you are taking certain medications that could interact with it. Treatment may be interrupted or dose can be lowered if patients experience certain adverse reactions.
Possible side effects: These are not all the possible side effects you may feel when taking venetoclax. In case you experience any side effects not listed here, contact your healthcare practitioner.
- Diarrhea
- Constipation
- Nausea
- Vomiting
- Decreased appetite
- Weight loss
- Stomach pain
- Weakness
- Mouth sores
- Shortness of breath
- Rash
- Fever
- Headache
- Dizziness
- Feeling tired
- Cough
- Itching
- Swelling of arms/legs/hands/feet
- chronic lymphocytic leukemia (CLL)
- small lymphocytic lymphoma (SLL)
- acute myeloid leukemia (AML)
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