Ibrutinib is a
small molecule drug that binds permanently to a protein Bruton's tyrosine kinase (BTK). Ibrutinib is indicated for B cell Cancers
e.g. Mentle cell Lymphoma (who has received at least one prior treatment),
Chronic Lymphocytic Leukemia (CLL) and small Lymphocytic Leukemia (SLL) etc.
Ibrutinib was jointly
developed and commercialized by Janssen Biotech and AbbVie Company
Pharmacyclics.
The 1st approval
of Ibrutinib was granted by USA FDA in 2013. This is available as brand name
Imbruvica in 90 and 120 packs. The print price of Imbruvica 140 mg capsules (90
tablet packs) is 328000 INR. There was no generic available till 2016.
Following four brands were introduced by manufacturing companies based in
Bangladesh in 2016.
Brand Name
|
Dosage Form
|
Strength
|
Company
|
|
Ibrucent
|
Capsule
|
140 mg
|
Incepta Pharmaceuticals Limited
|
|
Ibrunib
|
Capsule
|
140 mg
|
Julphar Bangladesh Ltd.
|
|
Ibrutinix
|
Capsule
|
140 mg
|
Everest Pharmaceuticals Ltd.
|
|
Ibrutix
|
Capsule
|
140 mg
|
Beacon Pharmaceuticals Ltd.
|
Indian patients did
not have any choice till December’2019 but to buy innovator brand which was
very expensive. Natco (Pharmaceutical company based in India) Introduced
generic version of Ibrutinib 140 mg by the brand name of Ibrunat in
December’2019. The details are as follows:
Brand Name: Ibrunat
Generic Composition: Ibrutinib
140 mg
Strength: 140 mg
Packing: Pack of 30
capsules
Price / pack: 9500 INR
Generic Ibrutinib will
help many more patients in getting access to the treatment. Most of the
patients were not able to afford innovators product as the price was very high.
The difference in price is significant. Each capsule of Imbruvica costs 3644 INR
whereas the price of one capsule of Ibrunat is 105 INR. Innovator brand is 34
times more expensive.
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