L‐asparaginase Treatment in Acute Lymphoblastic Leukemia

What is Erwinaze Used for? 

Erwinaze is a brand name of L-asparaginase, which is used as a component of a multi-agent chemotherapeutic regimen in order to treat patients with acute lymphoblastic leukemia (ALL).

What type of enzyme is asparaginase?

L-asparaginase is a kind of enzyme that catalyses specifically the asparagine hydrolysis in the l-aspartic acid as well as ammonium. 

How should L-asparaginase be given? 

In order to treat acute lymphoblastic leukemia (ALL), l-asparaginase dose should be given by injection into a vein, muscle, or under the skin.

Side Effects: The following serious side effects occur with l-asparaginase treatment: 

• Anaphylaxis
• Serious allergic reactions 
• Serious thrombosis 
• Pancreatitis 
• Glucose intolerance 
• Coagulopathy
• Abnormal liver function 
• Posterior Reversible Encephalopathy Syndrome (PRES) 
• Risk of Medication Errors

The most commonly reported side effects with asparaginase 10000 iu are elevated transaminases, hyperbilirubinemia, hyperglycemia, central nervous system (CNS), pancreatitis, thrombosis, coagulopathy, and allergic reactions (including anaphylaxis). 

Contraindications:

• Serious allergic reactions to asparaginase 10000 iu or any other existing components of it. 
• Serious thrombosis with prior the therapy with L-asparaginase 
• Pancreatitis with prior the therapy with L-asparaginase 
• Serious hemorrhagic events with prior the therapy with l asparaginase injection. 

Storage: Keep vials refrigerated at 2°C-8°C (36°F-46°F). Protect from light. Do not freeze. The I asparaginase injection does not contain a preservative. Store unused, reconstituted solution at 2°C-8°C (36°F-46°F) and discard after 8 hours or sooner in case it becomes cloudy.

Price of I-asparaginase injection: In order to know the price of this injection, kindly go through with A Quick Guide on L-asparaginase. 

NOTE: The piece of information mentioned about "L‐asparaginase Treatment in Acute Lymphoblastic Leukemia" in this article is just for informational purposes and is not served as a substitute for the medical treatment, consultation, diagnosis of an experienced or qualified healthcare professional.

 

Rheumatoid Arthritis: A Quick Guide

 Rheumatoid arthritis: Rheumatoid arthritis is a condition that can be responsible for causing pain, swelling and stiffness in the joints. 

It is known as a condition of autoimmune, which means that our body's immune system gets confused and starts attacking our body’s healthy tissues. In the condition of RA, inflammation in the joints is the major complication. 

Types: There are majorly two types of rheumatoid arthritis, which is listed as follows:

• Seropositive RA
• Seronegative RA

Symptoms: The major rheumatoid arthritis symptoms are:

• Joint pain
• Stiffness
• Joint swelling, warmth and redness

Some other symptoms may also include:

• Tiredness
• Lack of energy
• Not feeling hungry
• Weight loss
• Fever 
• Sweating
• Dry eyes
• Chest pain

RA may be responsible for affecting any joint in the body, despite it often occurs in the tiny joints in the hands as well as feet first. 

Causes: For rheumatoid arthritis causes some following can play a part in why someone has rheumatoid arthritis:

• Age
• Sex
• Genetics
• Weight
• Smoking
• Excess vitamin C

Rheumatoid Arthritis Treatment: In order to treat RA, there are a variety of treatments. The earlier the treatment is initiated, the more likely it is effective. 

There are mainly 3 major ways in order to treat RA (Rheumatoid Arthritis):

• Drugs
• Physical therapies
• Surgery

Drugs: There are 4 major groups of drugs that are recommended in order to treat RA. These are as follows:

• Painkillers 
• Non-steroidal anti-inflammatory drugs (NSAIDs)
• Steroid treatment (also known as corticosteroids)
• Disease-modifying anti-rheumatic drugs (DMARDs)

Effective Rheumatoid Arthritis Drugs: There are several drugs that are believed to work effectively for the rheumatoid arthritis cure. 

Azathioprine (Conventional synthetic DMARD): Being a DMARD, azathioprine is prescribed in order to manage the signs and symptoms of rheumatoid arthritis. Corticosteroids and nonsteroidal anti-inflammatory medicines can be combined with azathioprine 50 mg, but use together with other DMARDs should be avoided. 

The common adverse reactions due to this drug may include bone-marrow suppression and vomiting

Hydroxychloroquine (Conventional synthetic DMARD): Hydroxychloroquine can be used for the treatment of rheumatoid arthritis. It is consumed by mouth, often in the form of the hydroxychloroquine sulfate. 

The common adverse reactions due to hydroxychloroquine may include headache, changes in vision, muscle weakness and vomiting. 

Leflunomide (Conventional synthetic DMARD): Acts by inhibiting dihydroorotate dehydrogenase, Leflunomide, an immunosuppressive DMARD, is used in active moderate-to-severe rheumatoid arthritis. 

The most common adverse reactions due to this medication may include; respiratory tract infections, diarrhea, high blood pressure, rash, hair loss, nausea, headache, abdominal pain, bronchitis, back pain, urinary tract infection, dizziness, indigestion, itchiness, loss of appetite, weight loss, cough, gastroenteritis, vomiting, allergic reaction, weakness, chest pain, dry skin and eczema. 

Etanercept (Biologic; Anti-TNF): By interfering with the tumor necrosis factor, etanercept injection is used in order to treat rheumatoid arthritis. 

The common adverse reactions may include blocked/runny nose, sore throat, feeling sick, vomiting, mild fever, headaches, dizziness, rash and stomach pain. 

Adalimumab (Biologic; Anti-TNF): As a disease-modifying antirheumatic drug and monoclonal antibody, adalimumab injection is prescribed for the treatment of rheumatoid arthritis. 

The common adverse reactions may include rash, upper respiratory tract infections, pain at the site of injection, and headache

Apart from all these medications, there are some other medications that are widely used for the management of rheumatoid arthritis. These are listed as follows:

• Infliximab
• Methotrexate
• Sulfasalazine
• Rituximab
• Baricitinib
• Tofacitinib
• Sarilumab
• Certolizumab pegol
• Golimumab
• Abatacept
• Tocilizumab

NOTE: The piece of information provided in this article is just for informational purposes and is not served as a substitute for the medical treatment, consultation, diagnosis, of a qualified healthcare practitioner.

FAQ's

What is the first sign of rheumatoid arthritis? 

Stiffness, followed by pain and tenderness in the joints, typically is the first sign of RA. 

How long does it take to diagnose RA (rheumatoid arthritis)?

Most of the time, it happens in the first a couple of years. Your healthcare practitioner may perform blood tests as well as X-rays in order to detect a diagnosis.

What are the 4 stages of rheumatoid arthritis? 

As rheumatoid arthritis progresses, the body starts changing. Some changes are noticeable and you can feel, while others you cannot. Every stage of rheumatoid arthritis comes along with the different treatment goals.

Stage 1: It is an early stage of rheumatoid arthritis. 

Stage 2: It is a moderate stage of rheumatoid arthritis. 

Stage 3: It is a severe stage of rheumatoid arthritis. 

Stage 4: It is an end-stage of rheumatoid arthritis. 

Source:-Orginal content are here

Trastuzumab: A Breast Cancer Treatment

 What is trastuzumab?

Trastuzumab belongs to targeted (biological) therapy, which blocks the growth and spread of cancer. They target as well as interfere with processes in the cells that are believed to help cancer grow. Patients may have a brand of trastuzumab injection named Herceptin, or may have a biosimilar. 

Mechanism of Action?

Some breast cancer cells contain a higher than normal level of HER2 protein on their surface, which is involved in stimulating them in order to grow. 

Around 1 in 5 invasive breast cancers have this and are known as HER2 +Ve. 

Trastuzumab acts in order to attach itself to HER2 proteins so that the cancerous cells are no longer stimulated to grow. It also benefits the immune system to destroy breast cancer cells.

Who might be offered trastuzumab?

Only individuals with HER2 +Ve breast cancer will benefit from trastuzumab. In case your cancer is HER2 -Ve, then this medication will not be of any sort of benefit. 

There are multiple tests in order to measure the level of HER2, performed on breast tissue eliminated during a biopsy/surgery. 

The HER2 testing is basically only performed on invasive breast cancer, so it’s unlikely to be mentioned in case you've an early form of breast cancer named ductal carcinoma in situ (DCIS).

Trastuzumab 440 mg injection may not be useful for individuals with heart complications or hypertension that’s not well controlled. In case your breast cancer is HER2 +Ve and you have heart complications, your doctor will usually perform additional tests in order to check how effectively your heart is functioning.

When is trastuzumab given:

The trastuzumab injection can be used as a treatment of certain conditions, listed as follows:

• Primary breast cancer
• Breast cancer recurrence
• Secondary breast cancer

How is trastuzumab given:

Trastuzumab 440 mg comes in order to be administered as a drip into a vein (intravenous infusion) in your arm/hand. 

This medication can also be administered as an injection into the fatty tissue under the skin (subcutaneous injection) in your thigh. 

Trastuzumab is most commonly administered once every three weeks. Some individuals have it weekly. You will usually take your breast cancer treatment as an outpatient at the hospital, although a few individuals are able to take their treatment at home.

How long will I have trastuzumab for:

In case you’re having trastuzumab in order to treat primary breast cancer following surgery it’s usually administered for 1-year (around 18 cycles). 

In case you’re having trastuzumab prior to the surgery you’ll usually have four to six cycles.

In case you’re having trastuzumab in order to treat secondary breast cancer it’s basically administered for as long as it manages to control your cancer.

Possible side effects of trastuzumab:

Like other treatments, trastuzumab may also cause side effects. These side effects may be managed and those listed here will not be responsible for affecting everyone.

In case you’re concerned about any of the side effects, regardless of whether they‘re listed here, discuss with your doctor promptly.

Common side effects are as:

• Fever
• Chills
• Mild pain
• Nausea
• Diarrhoea
• Soreness at the injection site

Less common adverse reactions: Following the first treatment you may have other adverse reactions including: 

• Headaches
• Dizziness
• Joint and muscle pain
• Rash
• Vomiting (being sick) 
• Breathlessness 

These adverse reactions are often mild and don’t usually carry on with future treatments.

Price of Trastuzumab: The trastuzumab price in india may vary from generic to branded drugs. Price for a bottle of 50mL infusion of brand of trastuzumab named Herceptin is around 110700 INR. 

How much does trastuzumab cost?: In order to know please read- Trastuzumab 440 mg price

NOTE: The piece of information provided about "Trastuzumab: A Breast Cancer Treatment" in this article is just for informational purposes and is not served as a substitute for the medical treatment, consultation, diagnosis of a qualified healthcare practitioner.

FAQ's

What are the other approved drugs for breast cancer? 

Apart from Trastuzumab, there are several other approved and widely used drugs for breast cancer. The breast cancer drugs list is as follows:

• Afinitor (Everolimus)
• Aredia (Pamidronate Disodium)
• Arimidex (Anastrozole)
• Aromasin (Exemestane)
• Ellence (Epirubicin Hydrochloride)
• 5-FU (Fluorouracil Injection)
• Fareston (Toremifene)
• Faslodex (Fulvestrant)
• Femara (Letrozole)
• Gemzar (Gemcitabine Hydrochloride)
• Halaven (Eribulin Mesylate)
• Ibrance (Palbociclib 125mg) 
• Infugem (Gemcitabine Hydrochloride)
• Ixempra (Ixabepilone)
• Kadcyla (Ado-Trastuzumab Emtansine)
• Keytruda (Pembrolizumab)
• Kisqali (Ribociclib)
• Lynparza (Olaparib)
• Margenza (Margetuximab-cmkb)
• Nerlynx (Neratinib Maleate)
• Perjeta (Pertuzumab)
• Phesgo (Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf)
• Piqray (Alpelisib)
• Soltamox (Tamoxifen Citrate)
• Talzenna (Talazoparib Tosylate)
• Taxotere (Docetaxel)
• Tecentriq (Atezolizumab)
• Tepadina (Thiotepa 15mg) 
• Trexall (Methotrexate Sodium)
• Tykerb (Lapatinib Ditosylate)
• Verzenio (Abemaciclib)
• Xeloda (Capecitabine)
• Zoladex (Goserelin Acetate)

Is trastuzumab effective for breast cancer?

Trastuzumab following chemo is effective in HER2 +Ve Breast Cancer. The trastuzumab treatment for one year after the standard chemo improved disease-free survival in women with HER2 +Ve early breast cancer. 

What are the risk factors of breast cancer? 

Certain breast cancer risk factors are listed as follows:

• Being female
• Obesity
• Lack of exercise, alcohol
• Hormone replacement therapy during menopause
• Ionizing radiation
• Early age at first menstruation
• Having babies later in the phase of life or not at all. 
• Older age
• Prior breast cancer
• Family history of breast cancer
• Klinefelter syndrome

What is usually the first sign of breast cancer?

• Painless lumps in the breast.
• Thickening of the breast. 
• Nipple or breast skin change, such as redness, dimpling, or puckering.
• Discharge of fluid from the nipples. 

Is Stage 3 breast cancer curable?

With the help of aggressive treatment, Stage III breast cancer is curable; although, the risk that the breast cancer will grow back following treatment is high.

What is the last stage of breast cancer?

The stage-4 breast cancer, also known as metastatic breast cancer, is the most advanced breast cancer stage. By this stage, breast cancer is harder to cure because it has reached beyond the breast and can be responsible for affecting vital organs (lungs or brain).

Venetoclax Patient Assistance

 What is Venetoclax used for?

Chronic Lymphocytic Leukemia (CLL): Venetoclax is used for the treatment of adults with CLL. It is prescribed with another drug named obinutuzumab. This is used when CLL has not been treated earlier. Venetoclax can be used with another drug named rituximab. This is used when CLL has recurrence or has not responded to treatment. Venetoclax can also be used by itself when CLL has a chromosome deletion and has recurrence or has not responded to treatment; or has no chromosome deletion and other therapies are unavailable.

Chronic Lymphocytic Leukemia is a type of cancer that primarily affects the lymph nodes and WBCs named “B lymphocytes”. In this disease, unhealthy B lymphocytes multiply rapidly and live excessively. This causes there to be excess of them in the blood. 

Acute Myeloid Leukemia (AML): Venetoclax is used for the treatment of adults with Acute Myeloid Leukemia whose disease has not been treated earlier, and who are at least aged 75 years or have medical conditions that prevent them from having other types of chemo. For these patients, venetoclax 100 mg should be taken with another medication. It could be either azacitidine or low-dose cytarabine.

Acute Myeloid Leukemia (AML) is a cancer of the bone marrow and the blood. It primarily affects WBCs that are not fully mature known as myeloid blasts. In this disease, there are changes in the myeloid blasts that inhibit them from becoming mature blood cells. These immature blasts build up in the bone marrow and blood. This inhibits the normal cells from being produced and causes there to be a lower number of healthy blood cells.

Mechanism of Action: Venetoclax works in order to inhibit a protein in the body named BCL-2. This is a specific protein that helps cancerous cells survive. Inhibiting this protein helps to destroy and reduce the number of cancerous cells.

How to take VENCLEXTA?

The venclexta 100 mg tablet should always be taken exactly as your healthcare practitioner tells you. Drink plenty of water when taking treatment with this medication to help reduce the risk of getting TLS. Tablets should be administered with a meal and water at the same time each day. Swallow the tablets of venclexta whole. Do not chew, crush, or break the tablets. Your doses may be lower in some cases, including if you have severe liver problems, or in case you are taking certain medications that could interact with it. Treatment may be interrupted or dose can be lowered if patients experience certain adverse reactions.

Possible side effects: These are not all the possible side effects you may feel when taking venetoclax. In case you experience any side effects not listed here, contact your healthcare practitioner. 

• Diarrhea
• Constipation
• Nausea
• Vomiting
• Decreased appetite
• Weight loss
• Stomach pain
• Weakness
• Mouth sores
• Shortness of breath
• Rash
• Fever
• Headache
• Dizziness
• Feeling tired
• Cough
• Itching
• Swelling of arms/legs/hands/feet

Overdose: If you think you have taken an excess venetoclax dose, immediately call your healthcare practitioner, hospital emergency department, even if you have no symptoms.

Missed dose: In case of less than 8 hours, take your missed dose promptly. In case of more than 8 hours, skip the missed dose and take the upcoming dose at about usual time the next day. In case you vomit following taking your dose, avoid taking an extra dose. Take the next dose at about your usual time the next day. 

Storage: Store venetoclax tablets between 2 and 30°C. Keep out of reach as well as sight of children.

Note: The information provided in this article named "Venetoclax Patient Assistance", is only for informational purposes and is not served as a substitute for the medical treatment, consultation, diagnosis, of a qualified doctor. more other  Patient Information for Venetoclax

FAQs

What is Venclexta used for? 

Venclexta is a prescription medication used for the treatment of adults with:

• chronic lymphocytic leukemia (CLL)
• small lymphocytic lymphoma (SLL)
• acute myeloid leukemia (AML)

Is Venclexta chemotherapy? 

Technically, Venclexta (venetoclax) is a type of targeted therapy rather than chemotherapy.

How long do you administer Venclexta?

You will continue to administer Venclexta once a day until the end of the 12 month therapy. It should be taken at the standard daily dose as prescribed until your doctor instructs you to stop taking it or changes your dose.

How much does Venclexta cost? 

As with all medications, the cost of Venclexta can vary. In order to get the best venetoclax price, kindly contact us at our TOLL-FREE No: 1800-889-1064.

Lysodren: Information for the Patient

 About Lysodren: Lysodren (Mitotane: API) is an antitumoral medicine. It is introduced to treat symptoms of advanced non operable, metastatic or recurrent malignant tumours of the adrenal glands.

How to take Lysodren?

Always take lysodren tablets exactly as your healthcare professional has told you. You should swallow the tablets with a glass of water during meals containing fat-rich food. You can split the total daily dose in 2/3 intakes.

Dose and schedule: The usual starting dose for adult patients is 2-3 g (4 to 6 tablets) per day. Your healthcare professional may start therapy at higher doses such as 4-6 g (8 to 12 tablets). In order to find the optimal dose for you, your healthcare provider will monitor you regularly the levels of lysodren 500 in your blood. Your healthcare professional may decide to stop the lysodren treatment temporarily or to decrease the dose if you experience certain side effects.

Use in children and adolescents: The starting daily dose of mitotane tablets is 1.5 to 3.5 g/m2 body surface (this will be calculated by your healthcare practitioner according to the weight as well as the size of the child). The experience in patients in this age group is very limited.

Side Effects: The following side effects linked with the use of Lysodren (mitotane 500mg) were detected in clinical trials or observed in the postmarketing reports. Because these side effects were observed voluntarily from a group of uncertain size, it is not always possible to estimate frequency reliably or to establish a formal relationship to medication exposure. 

Common occurring lysodren side effects may include: anorexia, nausea, vomiting, diarrhea, depression, dizziness, growth retardation, rash, neutropenia, hypothyroidism, confusion, headache, mental impairment, weakness, dysarthria, ataxia and maculopathy. 

Less common occurring side effects include: visual blurring, prolonged bleeding time, lens opacity, diplopia, retinopathy, hemorrhagic cystitis, albuminuria, hematuria, hypertension, orthostatic hypotension, generalized aching, fever and flushing. 

Lysodren with food and drink: The Lysodren (mitotane tablets ) should preferably be taken during meals containing fat-rich food such as milk, chocolate, oil.

Pregnancy, breast-feeding and fertility: The mitotane use may harm the foetus. In case you are pregnant or want to become pregnant, tell your healthcare professional. In case you may become pregnant, you must use an effective contraception while on therapy with Lysodren and even after stopping it, discuss with your healthcare team for advice. You should avoid breast-feeding while taking Lysodren and even after stopping the therapy. Discuss with your healthcare professional for advice.

Driving and using machines: Treatment with Lysodren has a major influence on the ability to drive as well as use machines. Discuss with your healthcare professional for advice.

Other medicines and Lysodren: Please inform your healthcare provider in case you are using or have recently used any drugs, including any medicines obtained without a prescription.

You must avoid using Lysodren with medicines containing spironolactone, often prescribed as a diuretic for heart, liver or kidney diseases.

Lysodren therapy may interfere with several medications. Therefore, you must inform your healthcare professional in case you are using medications containing any of the following active substances:

• warfarin or blood thinners, used for the prevention of blood clots. The dose of anticoagulant may need adjustment.
• antiepileptics
• rifabutin or rifampicin, used for the treatment of tuberculosis
• griseofulvin, used to treat fungal infections
• herbal preparations containing St. John’s wort (Hypericum perforatum)
• Sunitinib, etoposide: for the treatment of cancer. 

Overdose: Inform your healthcare provider immediately in case you have accidentally administered an excess lysodren dose than you should or in case a child has accidentally swallowed some.

Missed Dose: In case you accidentally miss Or forget a dose, just administer the next dose as scheduled. Avoid taking a double dose to make up for the missed or forgotten one.

Storage: Keep lysodren out of the sight as well as reach of children. Store this medication in the original packaging. Avoid using it after the expiry date stated on the carton and the bottle following EXP. Any unused product or waste material should be disposed of in accordance with the local requirements for the cytotoxic medicines. Never throw away any medications via wastewater or household waste. 

Price: As with all medications, the lysodren 500 mg price in India can vary. To buy this medicine at the best price, kindly contact us at our TOLL-FREE Number: 1800-889-1064.

NOTE: The piece of information provided in this fact sheet is intended to be helpful and educational, but it does not constitute an endorsement by us and is not meant to be a substitute for professional medical advice.

Ustekinumab: Medication Guide

About Ustekinumab: The Ustekinumab comes under the brand name Stelara. It is mainly a monoclonal antibody. Monoclonal antibodies are specific proteins that identifies and bind to certain proteins in the body. Ustekinumab belongs to a group of medications known qs ‘immunosuppressants’. These medications act in order to weaken the part of the immune system.

Indication: The ustekinumab injection is aimed to treat the certain following inflammatory diseases:

• Plaque Psoriasis: in adults as well as children aged 6 years and older. 
• Psoriatic Arthritis: in adult patients. 
• Moderate-Severe Crohn’s disease: in adult patients. 
• Moderate-Severe UC (Ulcerative Colitis): in adults patients. 

Dosage: The ustekinumab 45 mg injection is intended for use under the close guidance and supervision of a specialist experienced in order to treat conditions for which ustekinumab is intended. 

Adults aged 18 years or older with Psoriasis or Psoriatic Arthritis: The standard starting ustekinumab dose is 45 mg. Patients who weigh more than 100kg can start on a dose of 90mg instead of 45mg. Following the starting dose, patient will have the next dose 4 weeks later, and then every 12 weeks. 

Adults aged 18 years or older with Crohn’s disease or Ulcerative Colitis: During therapy, the first stelara dose of approximately 6 mg/kg will be administered by a healthcare provider through intravenous infusion. Following the starting dose, patient will have the next dose of 90 mg after 8 weeks, then every 12 weeks thereafter subcutaneously. In some patients, following the first injection under the skin, 90 mg can be administered every 8 weeks. 

Children/Adolescents aged six years or older with Psoriasis: Healthcare profesaional will work out the appropriate dose, including the volume of stelara injection to be injected to give the apt dose. The right dose will depend on patient's body weight at the time each dose is administered. A 45 mg vial is available for children who need to have less than the full 45mg dose. If patients weigh less than 60kg, the standard dose is 0.75 mg per kg body weight. If patients weigh 60-100 kg, the standard dose is 45 mg. If patients weigh more than 100 kg, the standard dose is 90 mg. After the starting dose, patients will have the next dose 4 weeks later, and then every 12 weeks.

Administration: Ustekinumab should always be used exactly as per the words told by a healthcare professional. Discuss with doctor about when you will receive your injections and follow-up appointments. The stelara 45 mg is administered as an injection under the skin (‘subcutaneously’). At the beginning of therapy, anyone from healthcare team may inject this medication. Although, you and your specialist may decide that you may inject this medicine yourself. In this case you will get the training on how to inject it yourself. 

Possible Side Effects: Ustekinumab may cause serious side effects, including:

Serious allergic reactions: Serious allergic reactions may occur with Ustekinumab. Stop using this drug and get immediate medical assistance in case you have the symptoms of serious allergic reactions including feeling faint, chest tightness, skin rash and swelling of face, tongue, eyelids and throat.

Lung inflammation: In some cases, lung inflammation may happen in recipients who receive Ustekinumab, and this may be serious. These lung complications may require to be treated. Report your healthcare professional promptly in case you have shortness of breath or a cough that is persistent during treatment with Ustekinumab.

Common ustekinumab side effects include:

• Nasal congestion, sore throat, and runny nose
• Redness at the injection site
• Upper respiratory infections
• Vaginal yeast infections
• Fever
• Urinary tract infections
• Headache
• Sinus infection
• Tiredness
• Bronchitis
• Itching
• Diarrhea
• Nausea and vomiting
• Stomach pain

The above listed are not the all possible side effects of Ustekinumab. Contact your doctor or healthcare provider for medical instructions about side effects.

Pregnancy and breast-feeding: It is preferable to avoid the ustekinumab uses in pregnancy. The effects of this medication in pregnant women are unknown. In case you're a woman of childbearing age, you are advised to avoid 

becoming pregnant and must consider the apt contraception while using ustekinumab and for minimum 15 weeks following the last dose of treatment. Interact with your doctor if you are pregnant, think you could be pregnant or are planning to conceive a baby. Discuss with your healthcare team if you're breast-feeding or are planning to breast-feed. You along with your specialist should decide in case you need to breast-feed or use ustekinumab -do not do both.

Driving and using machines: Ustekinumab has no or negligible influence on the capability to drive and use machines.

Overdose: In case you have used or have been administered too much Ustekinumab, talk to a specialist straight away. Always have the outer carton of the medication with you, even if it is empty.

Missed Dose: If you forget ustekinumab 45 mg injection dose, contact your healthcare team. It is not recommended to take a double dose for making up a forgotten dose.

Storage: Store Ustekinumab vials and prefilled syringes in a refrigerator between 36°F to 46°F (2°C to 8°C). Vials should be stored standing up straight. Store this medication in the original carton to protect it from light until time to use it. Neither freeze nor shake Ustekinumab.

Price: The stelara injection cost in India can vary. To know the exact stelara price as well as procurement details, kindly get in touch with us today at our TOLL-FREE No: 1800-889-1064.

Note: The information provided in the article named "Ustekinumab: Medication Guide", is just for informational purposes and it is not responsible for serving as a substitute for the medical treatment, consultation, diagnosis, of an experienced healthcare professional.

SOLIRIS: DOSING & ADMINISTRATION GUIDE

Rheumatoid arthritis and its treatment (Xeljanz- Tofacitinib) 2022-23

Worry and Maybe a Little Hope?

Today ration of Rheumatoid arthritis (RA) is 0.5-1%, with a woman to man ratio of 3:1. It is 4 to 5 times higher in women under 50 years and It’s start when your immune system Not Functioning properly and goes Awry and begins to attack your body’s tissues. It’s cause inflammation in the joints and sometime in other organs. Result, your joints get red, warm, Painful, swollen, Fatigue and Stiffness.

Medication: Tofacitinib (Trade name Xeljanz 5mg  and launched by Pfizer) is type of drug which work by interfering with the inflammatory process with the immune system that cause Rheumatoid arthritis. Xeljanz is a long-term treatment, most people will notice an improvement within four weeks.

Where to buy Xeljanz: The Indian Pharma is the only and easier Solution to buy Xeljanz (Tofacitinib) online in India, We deliver Medicines to our clients in more than 15 countries in 4 continents using the most reputed international courier or cargo companies like FedEx International Priority Courier/KLM and Emirates Freight Carriers.

Also Read: Melphalan 50 Mg

Our endeavor is to ensure that overseas patients in need get an easy access to most reputed and trustworthy Indian brands at best prices. We offered to Patients trouble free payment options, ensured fastest delivery of medicines and guaranteed best prices.

We are sure that we will be keen on taking-up this opportunity, so that maximum number of patients can be benefitted of these drugs and can be offered a DEFINITE HOPE of Clearing the Rheumatoid arthritis and lead a very healthy life without the worry of lurking threat underneath.

Read  For More Information 

Joint Pain Tablets

All You Need To Know About Brentuximab Vedotin

About Brentuximab Vedotin: Brentuximab Vedotin is used to treat patients with: 

Hodgkin lymphoma (HL) that has come back following a stem cell transplant or following two types of chemotherapy if you cannot receive a stem cell transplant. 

Systemic anaplastic large cell lymphoma (sALCL) that comes back following the treatment with chemotherapy. 

HL at increased risk of continuing or returning, as additional treatment following an autologous stem cell transplant (ASCT). 

Dosage Forms: Brentuximab comes under the brand name drug Adcetris. It is available in a single-use vial containing 50 mg of brentuximab vedotin for injection.

Administration: The recommended dosage of brentuximab vedotin is administered as an intravenous infusion over 30 minutes.

Usual dose: The dose is 1.8 mg/kg. If you have mild liver disease, the dose may be 1.2 mg/kg. If you have more serious liver or serious kidney disease, brentuximab use should be avoided. If you weigh more than 100 kg, your dose will be calculated as if your weight was 100 kg. You will receive brentuximab at three week intervals. Treatment with brentuximab will be stopped in case your disease gets worse or if you experience unacceptable side effects. 

If you are receiving brentuximab after an ASCT (autologous stem cell transplant), your therapy should begin within 4 to 6 weeks after ASCT or recovery from ASCT. Treatment with this drug will continue for up to 16 doses or until then your disease gets worse or if you experience unacceptable adverse events.

Possible Side Effects: These are not the entire possible side effects you may feel when taking brentuximab vedotin. In case you experience any side effects not mentioned here, contact your healthcare team promptly. Common side effects associated with the use of brentuximab include:

• Nausea
• Vomiting
• Fatigue
• Diarrhea
• Shortness of breath
• Low red blood cell counts
• Low white blood cell counts

Certain other side effects you may experience, which are fever, hair loss, muscle pain and itching. These side effects may develop during and following therapy with adcetris 50 mg injection.

Precautionary Measures:

• Do not use brentuximab if you have a known allergy to the medicinal or non-medicinal ingredients. 
• Use of brentuximab should be avoided if you are currently on another drug named bleomycin. Bleomycin must be stopped prior to starting brentuximab injection. 
• Avoid using Brentuximab in case you have or have had PML (Progressive Multifocal Leukoencephalopathy).
• Females who may become pregnant should use minimum two reliable methods of birth control while on and for 6 months following therapy with adcetris. Promptly report to your doctor if you become pregnant while on therapy. 
• Breastfeeding is restricted while you are receiving brentuximab. It is not known if the medication can get into breast milk, and therefore, into the baby. 
• Males should consider an appropriate method of barrier contraception while on and for 6 months after treatment with brentuximab vedotin 60 mg.
• Certain medications and foods (like grapefruit juice) may be responsible for changing the level of anti-mitotic in the body.

Overdose: It is unlikely that you will receive excess brentuximab as you will be closely monitored by healthcare professionals during your infusion. In case of overdose, contact a health care practitioner, hospital emergency department or regional Poison Control Center promptly, even if there are no symptoms.

Missed Dose: If you miss your appointment to receive brentuximab dose, you need to make every effort in order to receive the missed dose very quickly. Doses should not be given less than three weeks apart.

Storage: Store Brentuximab at 2°C to 8°C in the original carton. Protect it from light. Keep out of reach and sight of children.

Price: The brentuximab price in India can vary. In order to know the exact price as well as the procurement deets, kindly get in touch with us today at 9650877511

Note: The information provided in the article named "All You Need To Know About Brentuximab Vedotin", is just for informational purposes and it is not responsible for serving as a substitute for the medical treatment, consultation, or diagnosis, of an experienced healthcare professional.

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