- Medicine Name- Orenitram
- API- Treprostinil
- Strength- Extended-Release Tablets: 0.125 mg, 0.25 mg, 1 mg, 2.5 mg and 5 mg.
- Manufactured by- United Therapeutics Corp.
Medicinal Uses:
A prostacyclin mimetic called orenitram is prescribed by the World Health Organization (WHO Group 1) to treat pulmonary arterial hypertension (PAH).
To enhance exercise capacity and postpone the advancement of the disease. The majority of patients with WHO functional class II–III symptoms and etiologies of idiopathic or heritable PAH (66%) or PAH linked to connective tissue disease (26%), respectively, were included in the studies that shown efficacy.
Recommended Dosage
- Administration Instructions:
- Take Orenitram with food.
- Swallow the tablets whole; do not crush or break them.
Initial Dosing:
Start with a dose of 0.125 mg three times a day (TID) or 0.25 mg twice a day (BID).
Titration:
- Adjust the dose by 0.125 mg TID or 0.25 mg or 0.5 mg BID.
- Titrate not more frequently than every 3 to 4 days, depending on tolerance.
Transition from IV or SC Remodulin®:
If switching from intravenous (IV) or subcutaneous (SC) Remodulin, increase the Orenitram dose while simultaneously decreasing the IV/SC infusion rate.
Mild Hepatic Impairment (Child Pugh Class A):
- Initiate at 0.125 mg BID.
- Increment at 0.125 mg BID not more frequently than every 3 to 4 days.
Moderate Hepatic Impairment:
Avoid using Orenitram in patients with moderate hepatic impairment.
Note: Patients should follow these instructions carefully, and any adjustments to the medication should be made under the guidance of their healthcare provider.
Warning and Precautions:
- Don't stop taking medication suddenly. (2.5, 5.1)
- Orenitram pills may become trapped in a diverticulum in people suffering from diverticulosis.
Documentation & Availability in India:
If you are considering the import of Orenitram (Treprostinil) to India, please be aware that Orenitram can be imported by patients or government hospitals solely in the name of the patients. The following documentation is essential for the successful import of this medication:
Required Documentation for Import:
- A valid prescription from a qualified medical practitioner.
- Diagnostic reports of the patient.
- Government-issued identification proof for the patient, as recognized by the Government of India.
Order Confirmation Process:
The order for Orenitram (Treprostinil) will be confirmed upon the receipt of the following documents:
- A valid prescription from a qualified doctor.
- An import permit, if applicable.
Availability of Orenitram (Treprostinil) in India:
Orenitram (Treprostinil) is classified as a prescription pharmaceutical drug. Consequently, it legally requires a medical prescription to be dispensed. Indian Pharma Network (IPN) specializes in facilitating the import of cancer medicines through named patient supply (NPS), ensuring transparency and authenticity by sourcing from reputable suppliers in the USA, Canada, Europe, and Australia.
Orenitram (Treprostinil) can be made accessible to patients, doctors, and hospitals in various cities across India, including but not limited to Mumbai, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Srinagar, Jammu, Jaipur, Chandigarh, Ludhiana, Noida, Gurgaon, Lucknow, and Pune. To confirm an order, a valid prescription from a doctor and an import permit will be required.
IPN (Indian Pharma Network) is dedicated to facilitating the supply of Orenitram (Treprostinil)
(prescription medicines) to locations both within India and worldwide, while adhering to relevant legal requirements.
Our commitment lies in assuring quality and timely delivery to meet the healthcare needs of patients and medical professionals across the globe.
Sourcing & Delivery:
Indian Pharma Network is proficient in sourcing Orenitram (Treprostinil) from around the world and ensuring efficient delivery to patients. We provide worldwide access to the best available treatments and expedite prescription dispensing and delivery, with all prescriptions being dispensed and scrutinized by registered pharmacists before dispatching them to the patient's address, exclusively from New Delhi, India.
FAQ's
What does a treprostinil injection indicate?
The injection of treprostinil is used to treat pulmonary arterial hypertension symptoms. This hypertension affects the major blood vessel that supplies the lungs with blood from the ventricle, the right side of the heart.
What kind of medication is treprostinil?
Treprostinil belongs to a group of drugs known as platelet-aggregation inhibitors and vasodilators. It improves blood flow by relaxing blood vessels, notably those in the lungs.
Which treprostinil formulations are available?
There are three different ways to take treprostinil: as an inhalation, subcutaneous, or intravenous solution. For PAH patients, each formulation is helpful.
What is the treprostinil brand name?
Treprostinil is a vasodilator used to treat pulmonary arterial hypertension. It is marketed under the names Tyvaso for inhalation, Orenitram for oral usage, and Remodulin for infusion.
What is treprostinil's bioavailability?
Treprostinil has an oral bioavailability of 17%, and four to six hours after oral administration, the medication concentration reaches its maximum value. Food has an impact on treprostinil's oral absorption.
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